Pacific Biosciences
A. Positions and Honors.
Positions and Employment
1990-1993 Research Specialist, Center for X-ray Lithography, University of Wisconsin
at Madison
1993-1994 Graduate Teaching Assistant, Cornell University, Ithaca, NY
1994-1997 Department of Education Fellow, Cornell University, Ithaca, NY
1997-2000 Graduate Research Assistant, Cornell University, Ithaca, NY
2000-2001 Postdoctoral Associate, Cornell University, Ithaca, NY
2001-2004 President, Nanofluidics, Inc., Menlo Park, CA
2004-present Chief Technology Officer, Pacific Biosciences (formerly Nanofluidics,
Inc.), Menlo Park, CA
2005-present Principal Investigator of NHGRI grant
Other Experience and Professional Memberships
2007-present Sitting Member, ISD Study Section
2008-present Member, American Association for the Advancement of Science
2009-present Member American Society of Human Genetics
Honors
1995 American Association of Physics Teachers Award for Excellence in Undergraduate
Education
2003 TR100 Award: the top innovators under 35
2008 Distinguished Alumnus, University of Wisconsin
B. Selected peer-reviewed publications (in chronological order).
1. gA window into third-generation sequencingh, Schadt, E., Turner, S., & Kasarskis,
A. (2010). Human Molecular Genetics, 19(2), R227-240. doi:10.1093/hmg/ddq416
2. gA flexible and efficient template for circular consensus sequencing and
SNP detectionh, Travers, K., Chin, C.-S., Rank, D., Eid, J., & Turner,
S. (2011). Nucleic Acids Research, 38(15), e159. doi:10.1093/nar/gkq543
3. Real-Time DNA Sequencing from Single Polymerase Moleculesh, Korlach, J.,
Bjornson, K., Chaudhuri, B., Cicero, R., Flusberg, B., Gray, J., Holden, D.,
et al. (2010). Methods in Enzymology, 472, 431-455. doi:10.1016/s0076-6879(10)72001-2
4. gDirect detection of DNA methylation during single-molecule, real-time
sequencingh, Flusberg, B., Webster, D., Lee, J., Travers, K., Olivares, E.,
Clark, T., Korlach, J., et al. (2010). Nature Methods, 7(6), 461-467. doi:10.1038/nmeth.1459
5. gReal-time tRNA transit or single translating ribosomes at codon resolutionh,
Uemura, S., Echeverria Aitken, C., Korlach, J., Flusberg, B., Turner, S., & Puglisi,
J. (2010). Nature, 464, 1012-1017. doi:10.1038/nature08925
6. gReal Time DNA Sequencing from Single Polymerase Moleculesh, Eid, J., Fehr,
A., Gray, J., Luong, K., Lyle, J., Otto, G., Peluso, P., Rank, D., Baybayan,
P., Bettman, B., Bibillo, A., Bjornson, K, Chaudhuri, B., Christians, F., Cicero,
R., Clark, S., Dalal, R., deWinter, A., Dixon, J., Foquet, M., Gaertner, A.,
Hardenbol, P., Heiner, C., Hester, K., Holden, D., Kearns, G., Kong, X., Kuse,
R., Lacroix, Y., Lin, S., Lundquist, P., Ma, C., Marks, P., Maxham, M., Murphy,
D., Park, I., Pham, T., Phillips, M., Roy, J., Sebra, R., Shen, G., Sorenson,
J., Tomaney, A., Travers, K., Trulson, M., Vieceli, Wegener, J., Wu, D., Yang,
A., Zaccarin, D., Zhao, P., Zhong, F., Korlach, J. & Turner, S. (2009).
Science 323, 133-138.
7. gLong, Processive Enzymatic DNA Synthesis Using 100% Dye-Labeled Terminal
Phosphate-Linked Nucleotidesh, Korlach, J., Bibillo, A., Wegener, J., Peluso,
P., Pham, T.T., Park, I., Clark, S., Otto, G.A. & Turner, S.W. (2008).
Nucleosides, Nucleotides and Nucleic Acids 27, 1072-1082.
8. gParallel confocal detection of single molecules in real timeh. Lundquist,
P., Zhong, F., Zhao, P., Tomaney, A., Peluso, P., Dixon, J., Bettman, B., Lacroix,
Y., Kwo, D., McCullough, E., Maxham, M., Hester, K., McNitt, P., Grey, D.,
Henriquez, C., Foquet, M., Turner, S., Zaccarin, D., Optics Letters, Vol. 33,
Issue 9, pp. 1026-1028
9. gSelective aluminum passivation for targeted immobilization of single DNA
polymerase molecules in zero-mode waveguide nanostructuresh, Korlach, J., Marks,
P.J., Cicero, R.L., Gray, J.J., Murphy, D.L., Roitman, D.B., Pham, T.T., Otto,
G.A., Foquet, M. & Turner, S.W. (2008). Proc. Natl. Acad. Sci. U.S.A. 105,
1176-1181.
10. gImproved fabrication of zero-mode waveguides for single-molecule detectionh,
Foquet, M., Samiee, K., Kong, X., Chaudhuri, B., Lundquist, P., Turner, S.,
Freudenthal, J., Roitman, D., Journal of Applied Physics 103, 034301 (2008)
11. gZero-mode waveguides for single-molecule analysis at high concentrationsh,
M. J. Levene, J. Korlach, S. W. Turner, M. Foquet, H. G. Craighead and W. W.
Webb, Science. Jan 31 (2003) 299: 682-686. (Featured on cover)
12. gContinuous separation of biomolecules by the laterally asymmetric diffusion
array with out-of plane sample injection.h M. Cabodi, Y. F. Chen, S. W. Turner,
H. G. Craighead and R. H. Austin, Electrophoresis. (2002) V. 23(20):3496-503.
13. gEntropic recoil separation of long DNA moleculesh, M. Cabodi, S. W. Turner
and H. G. Craighead,
Anal. Chem. Oct (2002) V. 74 no. 20 pp. 5169-74. (Featured on cover)
14. gConfinement-induced entropic recoil of single molecules of DNA in a nanofluidic
structureh, S.
W. P. Turner, M. Cabodi and H. G. Craighead, Phys. Rev. Lett., 88 (12) 128103(4)
March 25 (2002)
15. gConfinement of fluorescence excitation for single molecule detection at
high concentrationh, S.
W. P. Turner, M. Levene, J. Korlach, W. W. Webb and H. G. Craighead, Proc.
of the Micro-total
Analysis Systems 2001 Symposium, Monterey, CA, USA 21-25 October 2001, Kluwer
Academic
Pulishers, Dordrect (2001) pp. 259-261 (ISBN 1-4020-0148-7)
C. Research Support
Completed Research Support
5 RC2 HG005618-02, Turner (PI) 9/2009-7/2011
NHGRI (National Human Genome Research Institute, NIH)
Direct Single Base-Pair Real-Time DNA Methylation Sequencing
The goal of this program is to enable direct DNA methylation profiling during
real-time DNA sequencing, without bisulfite conversion.
Role: Principal Investigator
5R01HG003710-01, Turner (PI) 8/2005 - 12/2008
NHGRI (National Human Genome Research Institute, NIH)
Real-time Multiplex Single-Molecule DNA Sequencing
The goal of this program was to develop technologies for a four-color, real-time,
multiplex single-molecule DNA
sequencing system that will enable sequencing of a mammalian genome for $50,000
by 2008, and $1000 by
2010.
Role: Principal Investigator
2R44 GM067303-02, Turner (PI) 9/2003 - 9/2004
HHS (Department of Health & Human Services, NIH)
Zero-Mode Waveguides for Single Molecule Detection
The goal of this program was to optimize zero-mode waveguide fabrication techniques
and characterization
methods.
Role: Principal Investigator
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